In late 2002, Murphy in Just Married dating Ashton Kutcher, her co-star began. Was a talent manager Jeff Kwatinetz, Murphy, he was a production assistant while working on the film Little Black Book, Joe Macaluso became engaged in December 2005. In August 2006, they ended their engagement. In May 2007, Murphy during a private ceremony in Los Angeles Jewish married screenwriter Simon Monjack Colombia. For three-and your life, Murphy, and her mother lived a half years in the same house Monjack.
In the early 2000s, Murphy has more weight, which led to rumors of cocaine addiction is lost. In 2005, Murphy Jane magazine to challenge the claims, saying: "No, just for the record, I never tried in my life, I have never seen, and I can not be too great to leave home will have to leave."